Clinical Pathology

Core Laboratory Services

The Core Laboratory provides rapid response services available 24 hours a day for routine chemistry, urine and fluid analysis, hematology, coagulation, and blood gases (Rapid Response Lab.) Most testing is completed within one hour of receipt of specimens in theCore Laboratory. The laboratory uses direct tube sampling from micro-collection blood tubes for many of its tests, minimizing the amount of blood and allowing the use of skin puncture specimens rather than venipuncture specimens.

Complex testing, including the areas of special hematology, blood lead testing, sweat chloride and breath hydrogen analysis, as well as comprehensive coagulation studies are provided as routine procedures.

Hematopathology

The Hematopathology Services at Nationwide Children’s Hospital, directed by Dr. Samir Kahwash, provide diagnostic services and consultation on hemoglobinopathies and special hematology testing.  They are responsible for reviewing peripheral blood and bone marrow changes in major hematological disorders in children, including types of anemias, thrombocytopenias, leukemias and others.  

They provide cell marker studies by flow cytometry in hematologic malignancies and reactive conditions with emphasis on correlation with morphologic findings.

Microbiology

The Microbiology section of the Clinical Microbiology and Immunoserology Laboratoryis a full service microbiology laboratory, specializing in pediatric microbiology. The Microbiology Laboratory performs a number of tests to support the diagnosis of infectious disease using culture, direct exams and susceptibility tests. Our services include aerobic and anaerobic bacteriology, mycobacteriology, mycology, parasitology, antigen/toxin detection, and susceptibility testing.

Immunoserology

The Immunoserology Laboratory provides testing for IgE-Specific Allergy. It also provides diagnostic testing for Celiac disease, Autoimmune diseases, Rheumatology and other diseases, as well as quantification of circulating antibodies and other humoral immunology testing. The humeral immunology area performs testing for the diagnosis and treatment of autoimmune diseases, as well as quantitative analysis of immunoglobulins and other blood proteins. Methods used include immuno-fluorescence, immuno-diffusion and nephlometry.

Virology

The Viral Diagnostic Laboratory employs both new and classic methods providing comprehensive viral isolation and identification, detection of viral antigens and determination of viral antibody status from clinical samples.

Molecular Microbiology

The Diagnostic Molecular Microbiology Laboratory has developed and clinically validated several "in-house" PCR-based microbial nucleic acid detection assays for the diagnosis of infectious diseases. We are committed to the continued review and evaluation of these and newer "in-house" as well as commercially available assays for clinical utility and potential implementation.

Cytogenetics and Molecular Genetics 

The Cytogenetics Laboratory has provided a valuable service to hospitals, clinics, and physicians across the state of Ohio, for over 30 years.  In addition to chromosome and FISH (fluorescence in situ hybridization) studies for a number of microdeletion syndromes,the Cytogenetics/Molecular Genetics laboratories offer Microarray analysis.

The Molecular Genetics Laboratory continues to expand its' selection of molecular testing that started in the mid-1990's. Dr. Gastier-Foster  serves as the director and has played a critical roll in its' development.  The laboratory currently offers many clinical tests and continues to expand test offerings in pediatric cancer and pediatric inherited diseases. 

Special Chemistry and Endocrinology

The TDM/Toxicology Laboratory performs testing 24/7, for quantitative levels of most therapeutic drugs along with screening for abused drugs. This area works closely with the clinical pharmacists in monitoring the therapeutic drug levels of hospitalized and clinic patients. The testing in this area is most often performed using immunoassay methods. Routine thyroid testing as well as more specialized testing for other hormones like Insulin, Growth Hormone, FSH & LH are done in the Endocrine area using immunoassay and chemiluminescent techniques.

Metabolic Chemistry

The Metabolic Chemistry Laboratory provides testing for inborn errors of metabolism using established methods, including HPLC, Anion-Exchange Column Chromatography, Gas Chromatography-Mass Spectrometry, and Liquid Chromatography Tandem Mass Spectrometry.

POCT/Quality Assurance

Regulatory Compliance and Decentralized Testing is responsible for serving as the laboratory's resource for the understanding and implementation of current regulations concerning all laboratory issues, as well as leading the laboratory's Quality Assurance Team.
They provide oversight of near-patient testing including evaluation of appropriateness and review for approval, monitoring for process compliance and personnel competency, and quality control including instrument functionality.

REGULATORY COMPLIANCE:  Management of all departmental regulatory and accreditation activities, including CLIA and CAP accreditation, relating to diagnostic lab testing and quality improvement.

 

 

Transfusion Services

The Transfusion Service is responsible for the procurement, processing, and distribution of all blood products given to our patients. We establish and maintain an adequate inventory of whole blood, red blood cells, platelet concentrates, plateletpheresis, and plasma to provide what our patients need. All of our blood products are obtained from the American Red Cross (ARC) from volunteer blood donors. One donation of whole blood can benefit up to three patients by the separation of the blood into red cells, platelet concentrates and plasma.

We are trained and competent to perform any testing needed to prepare compatible products for our patients. We do Blood Typing (ABO and RH) on all our specimens, antibody screening and compatibility testing on all our patients greater than 4 months that need blood. Also, we do any workups necessary to identify antibodies and the cause of a positive Direct Coombs (DAT). You might find us doing an elution, titer or a Platelet antibody test. We also manufacture all the blood products, from making a syringe of red cells for a neonate to irradiating a platelet or pooling 4 units of cryoprecipitate. We can do every facet of Blood Banking and are proud to be able to offer all these services to our patients.

Meet Our Clinical Pathology Team

Check out a complete list of our team with highlighting profiles.